
宋雷,男,漢族,1975年3月生,中共黨員,博士,副教授,碩士生導(dǎo)師
一、主要學(xué)習(xí)經(jīng)歷
1993.9-1997.6,蘭州醫(yī)學(xué)院,藥學(xué)專(zhuān)業(yè),醫(yī)學(xué)學(xué)士;
2003.9 – 2009.6,蘭州大學(xué),生態(tài)學(xué)專(zhuān)業(yè),理學(xué)博士;
二、主要工作簡(jiǎn)歷
1997.9-2003.8 甘肅省第二人民醫(yī)院藥劑科,藥師
2009.9-2012.5 中國(guó)科學(xué)院近代物理研究所輻射生物效應(yīng)研究室博士后工作站,博士后
2012.6-至今西北民族大學(xué)醫(yī)學(xué)部,副教授
三、教學(xué)科研工作及成果
(一)教學(xué)工作:
2012年6月-至今為西北民族大學(xué)醫(yī)學(xué)院機(jī)能學(xué)教研室專(zhuān)任教師,教授課程藥理學(xué)、醫(yī)用化學(xué)、民族藥學(xué)概論和臨床藥理學(xué)。
(二)科研工作:
在研項(xiàng)目:
中央高?;究蒲匈M(fèi)項(xiàng)目重點(diǎn)項(xiàng)目“8-氨基異紫堇堿誘導(dǎo)胃癌細(xì)胞凋亡和周期阻滯的分子機(jī)制研究”(31920190095),2019/04-2021/04,在研
主持完成項(xiàng)目:
國(guó)家自然科學(xué)基金青年基金項(xiàng)目“腎透明細(xì)胞癌干細(xì)胞表面標(biāo)志物的鑒定”(81000961),2011/01-2011/12,已結(jié)題;
中央高?;究蒲匈M(fèi)項(xiàng)目重點(diǎn)項(xiàng)目“異紫堇堿衍生物靶向腫瘤干細(xì)胞的研究”(31920130036),2013/04-2015/04,已結(jié)題;
中央高?;究蒲匈M(fèi)項(xiàng)目重大培育項(xiàng)目“無(wú)血清懸浮法構(gòu)建不同L-H狀態(tài)胃癌干細(xì)胞的研究”(31920160009),2016/04-2018/04,已結(jié)題。
參與完成項(xiàng)目:
國(guó)家民委項(xiàng)目“醋酸棉酚誘導(dǎo)腫瘤細(xì)胞DNA雙鏈斷裂機(jī)制研究”(12XBZ011),2012/8-2014/8.
發(fā)表論文著作:
Lei Song, Wenling Ye,Yong Cui, Jianzhong Lu, Yanna Zhang, Nan Ding, WentaoHu, Hailong Pei, Zhongjin Yue, Guangming Zhou, 2017. Ecoto-5’-nucleotidase(CD73) is a biomarker for clear cell renal carcinoma stem-like cells.Oncotarget 8(19):31977-31992.
Lei Song, Feng-Min Li*, Xian-Wei Fan, You-Cai Xiong, Wen-Qi Wang, Xu-Ben Wu,Neil C. Turner., 2009. Soil water availability and plant competition affect theyield of spring wheat. European Journal of Agronomy 31, 51-60.
Lei Song, Da-Wei Zhang, Feng-Min Li*, Xian-Wei Fan, Qiang Ma, Neil C.Turner., 2010. Soil water availability alters the inter- and intra-cultivar competitionof three spring wheat cultivars bred in different eras. Journal of Agronomy andCrop Science 196, 323-335.
Guan XK#,Song L# (共同一作), WangTC, Turner NC, Li FM*, 2015. Effect of drought on the gas exchange, chlorophyllfluorescence and yield of six different-era spring wheat cultures. Journal ofAgronomy and Crop Science 201:253-266.
Wei Wang,Wento Hu, Ya Wang, Yong An, Lei Song,Panfeng Shang, Zhongjin Yue, 2020. Long non-coding RNA UCA1 promotes malignantphenotypes of renal cancer cells by modulating the miR-182-5p/DLL4 axis as aceRNA. Molecular Cancer 19:18.
Zhao F, ZhaoJ, Song L, Zhang YQ, Guo Z, Yang KH,2017. The induction of apoptosis and autophagy in human hepatoma SMMC-7721cells by combined treatment with vitamin C and polysaccharides extracted from Grifola frondosa. Apoptosis22:1461-1472.
Zhang YQ,Zhao F*, Song L, Gan HY, Xie XF,2017. Systematic Review and Meta-analysis of Endostar Combined WithTranscatheter Arterial Chemoembolization (TACE) Versus TACE Alone forHepatocellular Carcinoma. Journal of Evidence-Based Complementary andAlternative Medicine. DOI:10.1177/2156587217730461
Fei Zhao,Yongfeng Wang, Lei Song, Jiaxin Jin,Yaqing Zhang, Hongyun Gan, Kehu Yang, 2017. Synergistic apoptotic effect ofD-Fraction from Grifola frondosa and Vitamin C on hepatocellular carcinomaSMMC-7721 cells. Integrative Cancer Therapies 16:205-214.
Jin Zhao*,Zhong Guo, Shuyan Pei, Lei Song,Chenjing Wang, Jianxiu Ma, Long Jin, Yanqing Ma, Renke He, Jianbin Zhong, YingMa and Hong Zhang, 2017. pATM and γH2AX are effective radiation biomarkers inassessing the radiosensitivity of 12C6+ in human tumorcells. Cancer Cell International 17:49-59.
Guan XK,Turner NC, Song L, Gu YJ, Wang TC,Li FM*, 2016.Soil carbon sequestration by three perennial legume pastures is greater indeeper soil layers than in the surface soil. Biogeosciences 13:527-534.
Yi Yu, WeiWang, Lei Song, Wentao Hu, Chi Dong,Hailong Pei, Guangming Zhou, Zhongjin Yue, 2015. Ecoto-5’-nucleotidaseexpression is associated with the progression of renal cell carcinoma. OncologyLetters 9:2485-2494.
Guo Z, ZhaoJ, Song L, Ma JX, Wang CJ, Pei SY,Jiang C, Li SB, 2014. Induction of H2AX phosphorylation in tumor cells bygossypol acetic acid is mediated by phosphatidylinositol 3-kinase (PI3K) family.Cancer Cell International 14:141-149.
Zhao J, GuoZ, Zhang H, Wang ZH, Song L, Ma JX,Pei SY, Wang CJ, 2013. The potential value of the neutral comet assay and rH2AXfoci assay in assessing the radiosensitivity of carbon beam in human tumor celllines. Radiol Oncol 47(3):247-257.
Lei Chang,Wentao Hu, Caiyong Ye, Bin Yao, Lei Song,Xin Wu, Nan Ding, Jufang Wang*, Guangming Zhou*, 2012. miR-3928 actives ATRpathway by target Dicer. RNA Biology 9, 10:1247-1254.
Xian-Wei Fan,Feng-Min Li*, Lei Song, You-CaiXiong, Li-Zhe An, Yu Jia, Xiang-Wen Fang., 2009. Defense strategy of old andmodern spring wheat varieties during soil drying. Physiologia Plantarum 136, 310-323.
宋雷,劉勇,馬偉林,陳林林,郭忠*.氟達(dá)拉濱聯(lián)合不同輻射作用于腎癌細(xì)胞株786-O的效果觀(guān)察[J].中華放射腫瘤學(xué)雜志,2016,25(6):646-651.(CSCD核心)
宋 雷,葉文凌*,劉勇,王偉,黃睿.一種改進(jìn)的腎透明細(xì)胞癌原代細(xì)胞培養(yǎng)方法[J].第三軍醫(yī)大學(xué)學(xué)報(bào),2016,38(8):714-717. (CSCD核心)
宋雷*,綻春蕊,楊世英,馬偉林,馬賢,柳軍璽. 杭黃菊提取物的體外抗菌活性研究[J].天然產(chǎn)物研究與開(kāi)發(fā),2015,27(3):455-458. (CSCD核心)
宋雷,郭忠,楊世英,趙晉.腎癌干細(xì)胞與表觀(guān)遺傳學(xué)調(diào)控研究進(jìn)展[J].中國(guó)腫瘤臨床,2013,40(23):1477-1480.(CSCD核心)
楊世英,柳軍璽,張?chǎng)危卫?/span>*.異紫堇堿衍生物抗菌及抑腫瘤作用的研究[J].食品與生物技術(shù)學(xué)報(bào),2015,34(1):79-83. (CSCD核心)
宋雷,一種腫瘤細(xì)胞原代培養(yǎng)的方法. 中國(guó)發(fā)明專(zhuān)利:ZL 2014 1 0117528.7[P],2016-6-1.
周光明,王菊芳,宋雷,葉文凌,裴海龍,張亞楠,丁楠,孫放,葉才勇,高笑菲,徐瑚珊.CD73作為腎透明細(xì)胞癌干細(xì)胞表面標(biāo)志物的應(yīng)用. 中國(guó)發(fā)明專(zhuān)利:ZL 2013 1 0181801.8[P], 2015-1-7.
獲獎(jiǎng)情況:
甘肅省高等學(xué)??茖W(xué)研究?jī)?yōu)秀成果獎(jiǎng)(科學(xué)技術(shù)):磷酸化組蛋白rH2AX在腫瘤診斷與治療中的應(yīng)用研究 自然科學(xué)類(lèi)一等獎(jiǎng)(2015KJ-029),5/6
甘肅省藥學(xué)發(fā)展獎(jiǎng):基于西北特色植物禿瘡花主要成分異紫堇堿的抗癌藥物開(kāi)發(fā)二等獎(jiǎng)(2015-Y2-04-R5)
四、社會(huì)兼職和社會(huì)服務(wù)
中國(guó)細(xì)胞生物學(xué)學(xué)會(huì)會(huì)員
甘肅省執(zhí)業(yè)藥師協(xié)會(huì)會(huì)員
中國(guó)流式細(xì)胞學(xué)會(huì)會(huì)員